Guía de Isora is a municipality in the western part of the island of Tenerife, one of the Canary Islands, and part of the province of Santa Cruz de Tenerife. Guía de Isora is north of the Tenerife Sur suburb. It is located about 90 km SW eitherway of the island's capital, NW of Los Cristianos and Las Américas of Arona and about 20 to 25 km NW of Reina Sofia Airport.

The population is 17,163 (ISTAC, 2003), its density is 119.67/km² and the area is 143.42 km² (some read 143.82 km²). The elevation is 580 m. Guía de Isora is north of the TF1 superhighway terminus and is passed with TF38 to the east. Farmlands are in the valley areas while forests and grasslands are situated within mount Teide.

Its economy are business, tourism (less commmon than in Arona) and agriculture until the 1990s, agriculture was the dominant industry in Adeje and the majority of the population were also rural.

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